Founded in September, 2023, the Fablab Macao Science Center is operated by Macao Science Center. Located in the lobby of Macao Science Center, FabLab is a multi-purpose scientific innovation space featuring highly intelligent, miniaturized, and safe CNC equipment, making it an important place to learn about engineering and technology and realize innovative ideas in practice. The CNC equipment includes 3D printers, 3D scanners, laser cutting machines, CNC sewing and embroidery machines, CNC tabletop engraving machines, single-chip and mechatronics integrated modules, etc.

FabLab Macao Science Center was awarded the "International Laboratory for Science Popularization of BeiDou Navigation Satellite System" by the Aerospace Science and Technology Working Committee of the China Association for Promoting International Economic & Technical Cooperation (CAPC) and the Satellite Navigation System Engineering Center of the China Academy of Aerospace Electronics Technology, and has set up "Science Popularization Experimental Curriculum on BeiDou Navigation Satellite System". Macao Science Center is the only organization that has obtained the exclusive authorization to launch this course in Macao. The equipment of BeiDou Laboratory includes BeiDou Navigation Teaching Kit, BeiDou Experimental Platform Software, BeiDou Communication Creative Development System, BeiDou Creative Material Package, "BeiDou + 5G" Comprehensive Training Platform, BeiDou Auto Driving Comprehensive Training Platform, BeiDou Teaching Animation Software, Satellite Science Popularization and Interactive Display System and Satellite Navigation Constellation Virtual Simulation. Experimental Software, etc.

Macao Science Center is committed to promoting STEM education to public. Lots of equipment such as 3D printers and CNC milling machines are purchased for fabricating the creations and realize the ideas of creators. Macao Science Center opens for public in afternoon of weekdays and weekends.